Dr Natividad Garrido Mesa

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Natividad Garrido Mesa
About
Teaching and learning
Research

About

I graduated in Pharmacy from the University of Granada (Spain) in 2007 and completed an MSc in Pharmaceutical Care. I conducted my PhD research in the Department of Pharmacology, evaluating the anti-inflammatory activity of immunomodulatory antibiotics in preclinical models of intestinal inflammation. I was awarded a PhD in Pharmaceutical Sciences in 2011 and an Extraordinary Doctorate Award. As a PhD fellow I was a visiting scientist at different universities including Harvard University and Trinity College Dublin among others. I moved to London in 2012 and joined the Department of Experimental Immunobiology at King's College London where I was a Postdoctoral Research Associate for four years working towards unveiling the role of the transcription factor T-bet in regulating Innate Lymphoid Cells function. I then joined the University of East London as a Lecturer in Pharmacology, where I spent four years teaching pharmacology and immunology in various degrees and started my small research group. I have recently joined the School of Life Sciences, Pharmacy and Chemistry at Kingston University as a Lecturer in Physiology and Pharmacology.

I started teaching in Higher Education during my PhD and my passion for teaching and learning has only grown stronger since then. I hold two Postgraduate Certificates in Education and was awarded Fellowship of the Higher Education Academy in 2017.I am also interested in bringing science closer to the public and schoolchildren. I have participated in science outreach organisation as Spanish Project manager of Native scientist and vice-director of the London constituency of the Society of Spanish Researchers in the UK (2014-2015)

My research interests are in the fields of Pharmacology and Immunology, my work focuses on the study of the regulation of mucosal immune responses and the validation of novel therapeutic strategies for the treatment of immune mediated diseases, in particular Inflammatory Bowel Disease (IBD).

Academic responsibilities

Senior Lecturer in Physiology and Pharmacology

Qualifications

  • PhD in Pharmaceutical Sciences (University of Granada, 2011)
  • MSc in Pharmaceutical Care (University of Granada, 2008)
  • BSc in Pharmacy (University of Granada, 2007)

Teaching and learning

Qualifications and expertise

  • Fellow, Higher Education Academy (2017)
  • Postgraduate Certificate in Academic Practice in Higher Education (University of Granada, 2012)
  • Postgraduate Certificate in Education C.A.P. (University of Granada, 2008)

Undergraduate courses taught

Postgraduate courses taught

Research

My research work is focused on the study of the regulation of mucosal immune responses in the context of intestinal inflammation and the validation of novel therapeutic strategies for the treatment of Inflammatory Bowel Diseases (IBD).

I have a small research group currently study how immunomodulatory antibiotics regulate the function and phenotype of macrophages and other innate immune cells and how this relates to their anti-inflammatory effect. I have supervised and currently supervise PhD, MSc and undergraduate students on this area of research.

I have also participated as a co-investigator in a variety of research projects searching for pharmacological alternatives for the treatment of other inflammatory and autoimmune conditions such as rheumatoid arthritis, diabetes and metabolic syndrome, with a particular interest in natural compounds (probiotics, prebiotics and medicinal plants).

Over the years, I have acquired a background in cellular immunology that complements my pharmacological training and contributes to my understanding of the pharmacology of immune-based therapies. I have expertise in the preclinical evaluation drugs in models of immunologically driven disease both in vivo (including genetically modified, tissue specific conditional knock outs and fluorescent reporter models), ex vivo (organ bath and explants) and in vitro (cell lines, co-cultures, immune cell culture). I have expertise in different histological, cellular and molecular techniques (multicolour flow cytometry and intracellular cytokine and transcription factor staining, ELISA, western blotting, microRNAs and mRNA RT-PCR).

Areas of specialism

  • Pharmacology
  • Immunology
  • Bioscience

Scholarly affiliations

  • Member of the British Pharmacological society (2017-present)
  • Member of the British Society of Immunology (2013-present)
  • Member of the Society of Spanish Researchers in the UK (2012-present)
  • Guest Associate Editor Frontiers in Pharmacology - Topic: Pharmacological Regulation of Innate Immune Cell Plasticity: a Novel Strategy for the Treatment of IBD?
  • Guest Associate Editor Frontiers in Immunology - Topic: The Gut-immune Axis: A Complex Training Ground Impacting Inflammatory Pathologies
  • Associate Editor Frontiers in Pharmacology - Experimental Pharmacology and Drug Discovery specialty section

Research student supervision

Publications

Jump to: Article | Thesis
Number of items: 25.

Article

Garrido-Mesa, Jose, Gálvez, Julio and Garrido-Mesa, Natividad (2023) Editorial : The gut-immune axis : a complex training ground impacting inflammatory pathologies. Frontiers in Immunology, 14, p. 1274761. ISSN (online) 1664-3224

Lo, Jonathan W., de Mucha, Maria Vila, Henderson, Stephen, Roberts, Luke B., Constable, Laura E., Garrido-Mesa, Natividad, Hertweck, Arnulf, Stolarczyk, Emilie, Houlder, Emma L., Jackson, Ian, MacDonald, Andrew S., Powell, Nick, Neves, Joana F., Howard, Jane K., Jenner, Richard G. and Lord, Graham M. (2022) A population of naive-like CD4⁺ T cells stably polarized to the T[sub]H1 lineage. European Journal of Immunology, 52(4), pp. 566-581. ISSN (print) 0014-2980

Garrido-Mesa, Jose, Adams, Kate, Galvez, Julio and Garrido-Mesa, Natividad (2022) Repurposing tetracyclines for acute respiratory distress syndrome (ARDS) and severe COVID-19 : a critical discussion of recent publications. Expert Opinion on Investigational Drugs, 31(5), pp. 475-482. ISSN (print) 1354-3784

Garrido-Mesa, N., Schroeder, J-H., Stolarczyk, E., Gallagher, A. L., Lo, J. W., Bailey, C., Campbell, L., Sexl, V., MacDonald, T. T., Howard, J. K., Grencis, R. K., Powell, N. and Lord, G. M. (2019) T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function. Mucosal Immunology, 12(1), pp. 51-63. ISSN (print) 1933-0219

Garrido-Mesa, J, Rodríguez-Nogales, A, Algieri, F, Vezza, T, Hidalgo-Garcia, L, Garrido-Barros, M, Utrilla, M P, Garcia, F, Chueca, N, Rodriguez-Cabezas, M E, Garrido-Mesa, N and Gálvez, J (2018) Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution. British Journal of Pharmacology, 175(23), pp. 4353-4370. ISSN (print) 0007-1188

Garrido-Mesa, J., Algieri, F., Rodríguez-Nogales, A., Vezza, T., Utrilla, M.P., Garcia, F., Chueca, N., Rodríguez-Cabezas, M.E., Garrido-Mesa, N. and Gálvez, J. (2018) Immunomodulatory tetracyclines ameliorate DNBS-colitis : impact on microRNA expression and microbiota composition. Biochemical Pharmacology, 155, pp. 524-536. ISSN (print) 0006-2952

Rodriguez-Nogales, A., Lozano-Pérez, A.A., Aznar-Cervantes, S.D., Algieri, F., Garrido-Mesa, J., Garrido-Mesa, N., Vezza, T., Utrilla, M.P., Cenis, J.L., Rodríguez-Cabezas, M.E. and Gálvez, J. (2016) Effect of aqueous and particulate silk fibroin in a rat model of experimental colitis. International Journal of Pharmaceutics, 511(1), pp. 1-9. ISSN (print) 0378-5173

Algieri, Francesca, Rodriguez-Nogales, Alba, Vezza, Teresa, Garrido-Mesa, Jose, Garrido-Mesa, Natividad, Utrilla, M. Pilar, González-Tejero, M. Reyes, Casares-Porcel, Manuel, Molero-Mesa, Joaquin, del Mar Contreras, Maria, Segura-Carretero, Antonio, Pérez-Palacio, José, Diaz, Caridad, Vergara, Noemí, Vicente, Francisca, Rodriguez-Cabezas, M. Elena and Galvez, Julio (2016) Anti-inflammatory activity of hydroalcoholic extracts of 'Lavandula dentata' L. and 'Lavandula stoechas' L. Journal of Ethnopharmacology, 190, pp. 142-158. ISSN (print) 0378-8741

Algieri, F., Rodriguez-Nogales, Al., Garrido-Mesa, J., Camuesco, D., Vezza, T., Garrido-Mesa, N., Utrilla, P., Rodriguez-Cabezas, M.E., Pischel, I. and Galvez, J. (2016) Intestinal anti-inflammatory activity of calcium pyruvate in the TNBS model of rat colitis : comparison with ethyl pyruvate. Biochemical Pharmacology, 103, pp. 53-63. ISSN (print) 0006-2952

Powell, Nick, Lo, Jonathan W., Biancheri, Paolo, Vossenkämper, Anna, Pantazi, Eirini, Walker, Alan W., Stolarczyk, Emilie, Ammoscato, Francesca, Goldberg, Rimma, Scott, Paul, Canavan, James B., Perucha, Esperanza, Garrido-Mesa, Natividad, Irving, Peter M., Sanderson, Jeremy D., Hayee, Bu, Howard, Jane K., Parkhill, Julian, MacDonald, Thomas T. and Lord, Graham M. (2015) Interleukin 6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation. Gastroenterology, 149(2), pp. 456-467. ISSN (print) 0016-5085

Garrido-Mesa, José, Algieri, Francesca, Rodriguez-Nogales, Alba, Utrilla, Maria Pilar, Rodriguez-Cabezas, Maria Elena, Zarzuelo, Antonio, Ocete, Mari Angeles, Garrido-Mesa, Natividad and Galvez, Julio (2015) A new therapeutic association to manage relapsing experimental colitis : Doxycycline plus 'Saccharomyces boulardii'. Pharmacological Research, 97, pp. 48-63. ISSN (print) 1043-6618

Rodríguez-Nogales, Alba, Algieri, Francesca, Vezza, Teresa, Garrido-Mesa, Natividad, Olivares, Mónica, Comalada, Mònica, Riccardi, Carlo, Utrilla, Maria Pilar, Rodríguez-Cabezas, Maria Elena and Galvez, Julio (2015) The viability of 'Lactobacillus fermentum' CECT5716 is not essential to exert intestinal anti-inflammatory properties. Food & Function, 4, pp. 1023-1372. ISSN (print) 2042-6496

Algieri, Francesca, Rodriguez-Nogales, Alba, Garrido-Mesa, Natividad, Zorrilla, Pedro, Burkard, Natalie, Pischel, Ivo, Sievers, Hartwig, Benedek, Birgit, Feistel, Bjorn, Walbroel, Bernd, Rodriguez-Cabezas, M. Elena and Galvez, Julio (2014) Intestinal anti-inflammatory activity of the 'Serpylli herba' extract in experimental models of rodent colitis. Journal of Crohn's and Colitis, 8(8), pp. 775-788. ISSN (print) 1873-9946

Toral, Marta, Gomez-Guzman, Manuel, Jimenez, Rosario, Romero, Miguel, Sanchez, Manuel, Utrilla, Maria Pilar, Garrido-Mesa, Natividad, Rodriguez-Cabezas, Maria Elena, Olivares, Monica, Galvez, Julio and Duarte, Juan (2014) The probiotic 'Lactobacillus coryniformis' CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice. Clinical Science, 127(1), pp. 33-45. ISSN (print) 0143-5221

Algieri, Francesca, Rodriguez-Nogales, Alba, Garrido-Mesa, Natividad, Vezza, Teresa, Garrido-Mesa, Jose, Utrilla, M. Pilar, Montilla, Antonia, Cardelle-Cobas, Alejandra, Olano, Agustin, Corzo, Nieves, Guerra-Hernandez, Eduardo, Zarzuelo, Antonio, Rodriguez-Cabezas, M. Elena and Galvez, Julio (2014) Intestinal anti-inflammatory effects of oligosaccharides derived from lactulose in the trinitrobenzenesulfonic acid model of rat colitis. Journal of Agricultural and Food Chemistry, 62(19), pp. 4285-4297. ISSN (print) 0021-8561

Lozano-Perez, Antonio Abel, Rodriguez-Nogales, Alba, Ortiz-Cullera, Victor, Algieri, Francesca, Garrido-Mesa, Jose, Zorrilla, Pedro, Rodriguez-Cabezas, M Elena, Garrido-Mesa, Natividad, Utrilla, M Pilar, De Matteis, Laura, de la Fuente, Jesus Martinez, Cenis, Jose Luis and Galvez, Julio (2014) Silk fibroin nanoparticles constitute a vector for controlled release of resveratrol in an experimental model of inflammatory bowel disease in rats. International Journal of Nanomedicine, 9(1), pp. 4507-4520. ISSN (print) 1176-9114

Cueto Sola, M., Bailon, E., Utrilla, P., Rodriguez-Ruiz, J., Garrido-Mesa, N., Zarzuelo, A., Xaus, J., Galvez, J. and Comalada, M. (2013) Active colitis exacerbates immune response to internalized food antigens in mice. International Archives of Allergy and Immunology, 162(3), pp. 214-224. ISSN (print) 1018-2438

Garrido-Mesa, N, Zarzuelo, A and Galvez, J (2013) Minocycline : far beyond an antibiotic. British Journal of Pharmacology, 169(2), pp. 337-352. ISSN (print) 0007-1188

Algieri, Francesca, Zorrilla, Pedro, Rodriguez-Nogales, Alba, Garrido-Mesa, Natividad, Banuelos, Oscar, González-Tejero, M. Reyes, Casares-Porcel, Manuel, Molero-Mesa, Joaquín, Zarzuelo, Antonio, Utrilla, M. Pilar, Rodriguez-Cabezas, M. Elena and Galvez, Julio (2013) Intestinal anti-inflammatory activity of hydroalcoholic extracts of 'Phlomis purpurea' L. and 'Phlomis lychnitis' L. in the trinitrobenzenesulphonic acid model of rat colitis. Journal of Ethnopharmacology, 146(3), pp. 750-759. ISSN (print) 0378-8741

Garrido-Mesa, Natividad, Algieri, Francesca, Rodriguez Nogales, Alba and Galvez, Julio (2013) Functional plasticity of Th17 cells : implications in gastrointestinal tract function. International Reviews of Immunology, 32(5-6), pp. 493-510. ISSN (print) 0883-0185

Garrido-Mesa, Natividad, Camuesco, Desirée, Arribas, Belén, Comalada, Mònica, Bailón, Elvira, Cueto-Sola, Margarita, Utrilla, Pilar, Nieto, Ana, Zarzuelo, Antonio, Rodríguez-Cabezas, María Elena and Gálvez, Julio (2011) The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties. Pharmacological Research, 63(4), pp. 308-319. ISSN (print) 1043-6618

Rodríguez-Cabezas, Maria Elena, Camuesco, Desirée, Arribas, Belén, Garrido-Mesa, Natividad, Comalada, Mònica, Bailón, Elvira, Cueto-Sola, Margarita, Utrilla, Pilar, Guerra-Hernández, Eduardo, Pérez-Roca, Carlos, Gálvez, Julio and Zarzuelo, Antonio (2010) The combination of fructooligosaccharides and resistant starch shows prebiotic additive effects in rats. Clinical Nutrition, 29(6), pp. 832-839. ISSN (print) 0261-5614

Bailón, Elvira, Cueto-Sola, Margarita, Utrilla, Pilar, Rodríguez-Cabezas, María Elena, Garrido-Mesa, Natividad, Zarzuelo, Antonio, Xaus, Jordi, Gálvez, Julio and Comalada, Mònica (2010) Butyrate 'in vitro' immune-modulatory effects might be mediated through a proliferation-related induction of apoptosis. Immunobiology, 215(11), pp. 863-873. ISSN (print) 0171-2985

Arribas, Belén, Suárez-Pereira, Elena, Ortiz Mellet, Carmen, García Fernández, José M., Buttersack, Christoph, Rodríguez-Cabezas, Maria Elena, Garrido-Mesa, Natividad, Bailon, Elvira, Guerra-Hernández, Eduardo, Zarzuelo, Antonio and Gálvez, Julio (2010) Di-d-fructose dianhydride-enriched caramels : effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats. Journal of Agricultural and Food Chemistry, 58(10), pp. 6476-6484. ISSN (print) 0021-8561

Thesis

Garrido Mesa, Natividad (2011) Minocycline in infammatory bowel disease : far beyond an antibiotic. (PhD thesis), Universidad de Granada, .

This list was generated on Wed Sep 13 07:07:09 2023 BST.