Professor Adam Le Gresley

Article

Long, Nathan, Le Gresley, Adam, Solomonsz, Arran, Wozniak, Antony, Brough, Steve and Wren, Stephen Paul (2023) Synthesis of squaric acid monoamides as building blocks for drug discovery. SynOpen, ISSN (online) 2509-9396 (In Press)

Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Naughton, Declan P (2023) High-resolution 1H NMR analysis of continuous and discontinuous thermo-oxidative susceptibility of culinary oils during frying at 180℃. Journal of Food and Drug Analysis, 31(1), pp. 95-115. ISSN (print) 1021-9498

Fudger, Alex, Cakir, Okan M., Khan, Yousaf, Sinclair, Alex and Le Gresley, Adam (2022) Chemical synthesis of a library of natural product-like derivatives based on pinnaic acid and initial evaluation of their anti-cancer activity. Organic & Biomolecular Chemistry, 47(20), pp. 9408-9421. ISSN (print) 1477-0520

Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Naughton, Declan P. (2022) Nuclear magnetic resonance spectroscopic analysis of the evolution of peroxidation products arising from culinary oils exposed to thermal oxidation : an investigation employing ¹H and ¹H-¹H COSY and TOCSY techniques. Foods, 11(13), p. 1864. ISSN (online) 2304-8158

Zecchini, Matteo, Lucas, Robert A., Robertson, Cameron, Coban, Tomris, Thatti, Ravtej and Le Gresley, Adam (2022) Investigation of the formation of squalene oligomers exposed to ultraviolet light and changes in the exposed squalene as a potential skin model. Molecules, 27(11), p. 3481. ISSN (online) 1420-3049

Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin, De Mars, Simon and Naughton, Declan P. (2022) The impact of partial oil substitution and trace metal ions on the evolution of peroxidation products in thermally stressed culinary oils. Food Chemistry, 375, p. 131823. ISSN (print) 0308-8146

Benardout, Miles, Le Gresley, Adam, ElShaer, Amr and Wren, Stephen P. (2022) Fructose malabsorption : causes, diagnosis and treatment. British Journal of Nutrition, 127(4), pp. 481-489. ISSN (print) 0007-1145

Robertson, Cameron, Raj, Nidhin, Lucas, Robert, Coban, Tomris and Le Gresley, Adam (2022) A proof-of-concept study utilising 2D NMR spectrometry for in situ characterisation and quantitation of key biomarkers and actives in tape stripped ex vivo human skin. Talanta, 237, p. 122980. ISSN (print) 0039-9140

Ampem, Gilbert, Le Gresley, Adam, Grootveld, Martin and Naughton, Declan P. (2021) The role of polydimethylsiloxane in suppressing the evolution of lipid oxidation products in thermo-oxidised sunflower oil : influence of stirring processes. Frontiers in Nutrition, 8, p. 721736. ISSN (online) 2296-861X

Goenaga Infante, Heidi, Warren, John, Chalmers, John, Dent, Geoffrey, Todoli, Jose Luis, Collingwood, Joanna, Telling, Neil, Resano, Martin, Limbeck, Andreas, Schoenberger, Torsten, Hibbert, D. Brynn, LeGresley, Adam, Adams, Kristie and Craston, Derek (2021) Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019). Pure and Applied Chemistry, 93(6), pp. 647-776. ISSN (print) 0033-4545

Long, Nathan, Le Gresley, Adam and Wren, Stephen (2021) Thiazolidinediones : an in depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus. ChemMedChem, 16(11), pp. 1717-1736. ISSN (print) 1860-7179

Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard and LeGresley, Adam (2021) Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands. RSC Medicinal Chemistry, 5, pp. 751-757. ISSN (online) 2632-8682

Dahabra, Layan, Broadberry, Grace, Le Gresley, Adam, Najlah, Mohammad and Khoder, Mouhamad (2021) Sunscreens containing cyclodextrin inclusion complexes for enhanced efficiency : a strategy for skin cancer prevention. Molecules, 26(6), p. 1698. ISSN (online) 1420-3049

Le Gresley, Adam, Ampem, Gilbert, De Mars, Simon, Grootveld, Martin and Naughton, Declan P. (2021) "Real-world" evaluation of lipid oxidation products and trace metals in French fries from two chain fast-food restaurants. Frontiers in Nutrition, 8, p. 620952. ISSN (online) 2296-861X

Awadh, Ammar A., Le Gresley, Adam, Forster-Wilkins, Gary, Kelly, Alison F. and Fielder, Mark D. (2021) Determination of metabolic activity in planktonic and biofilm cells of Mycoplasma fermentans and Mycoplasma pneumoniae by nuclear magnetic resonance. Scientific Reports, 11, p. 5650. ISSN (print) 2045-2322

Malik, Samerah, Sinclair, Alex, Ryan, Ali and Le Gresley, Adam (2020) Synthesis and initial evaluation of a novel fluorophore for selective FMDV 3C Protease detection. Molecules, 25(16), p. 3599. ISSN (online) 1420-3049

Percival, Benita C., Wann, Angela, Zbasnik, Richard, Schlegel, Vicki, Edgar, Mark, Zhang, Jie, Ampem, Gilbert, Wilson, Philippe, Le Gresley, Adam, Naughton, Declan and Grootveld, Martin (2020) Evaluations of the peroxidative susceptibilities of cod liver oils by a ¹H NMR analysis strategy : peroxidative resistivity of a natural collagenous and biogenic amine-rich fermented product. Nutrients, 12(3), p. 753. ISSN (print) 2072-6643

Robertson, Cameron, Lucas, Robert A. and Le Gresley, Adam (2020) Scope and limitations of nuclear magnetic resonance techniques for characterisation and quantitation of vitamin D in complex mixtures. Skin Research and Technology, 26(1), pp. 112-120. ISSN (print) 0909-752X

Bywaters, Luke and Le Gresley, Adam (2020) Synthesis and spectral properties of novel Singapore Green analogues for protease detection. Scientific Reports, 10, p. 259. ISSN (online) 2045-2322

Le Gresley, Adam, Ampem, Gilbert, Grootveld, Martin, Percival, Benita C. and Naughton, Declan P. (2019) Characterisation of peroxidation products arising from culinary oils exposed to continuous and discontinuous thermal degradation processes. Food and Function, 10, pp. 7952-7966. ISSN (print) 2042-6496

Zecchini, Matteo, Lucas, Robert and Le Gresley, Adam (2019) New insights into the cystine-sulfite reaction. Molecules, 24(13), p. 2377. ISSN (online) 1420-3049

Le Gresley, Adam, Broadberry, Grace, Robertson, Cameron, Peron, Jean-Marie, Robinson, Joshua and O'Leary, Shane (2019) Application of pure shift and diffusion NMR for the characterisation of crude and processed pyrolysis oil. Journal of Analytical and Applied Pyrolysis, 140, pp. 281-289. ISSN (print) 0165-2370

Le Gresley, Adam and Peron, Jean-Marie R. (2019) A semi-automatic approach to the characterisation of dark chocolate by Nuclear Magnetic Resonance and multivariate analysis. Food Chemistry, 275, pp. 385-389. ISSN (print) 0308-8146

Ghanbari, Arshia, Le Gresley, Adam, Naughton, Declan, Kuhnert, Nikolai, Sirbu, Diana and Ashrafi, G. Hossein (2019) Biological activities for 'Ficus carica' latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers. Scientific Reports, 9(1013), ISSN (online) 2045-2322

Vienescu, D.N., Wang, J., Le-Gresley, A. and Nixon, J.D. (2018) A life cycle assessment of options for producing synthetic fuel via pyrolysis. Bioresource Technology, 249, pp. 626-634. ISSN (print) 0960-8524

Butt, Ummara, ElShaer, Amr, Snyder, Lori A. S., Al-Kinani, Ali A., Le Gresley, Adam and Alany, Raid G. (2018) Fatty acid based microemulsions to combat ophthalmia neonatorum caused by 'Neisseria gonorrhoeae' and 'Staphylococcus aureus'. Nanomaterials, 8(1), p. 51. ISSN (online) 2079-4991

Bywaters, Luke, Mulcahy-Ryan, Lauren, Fielder, Mark, Sinclair, Alex and Le Gresley, Adam (2017) Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of 'Staphylococcus aureus'. Molecular and Cellular Probes, 36, pp. 1-9. ISSN (print) 0890-8508

Fardus-Reid, Fahmina, Warren, John and Le Gresley, Adam (2016) Validating heteronuclear 2D quantitative NMR. Analytical Methods, 8(9), pp. 2013-2019. ISSN (print) 1759-9660

Le Gresley, A, Gudivaka, V, Carrington, S, Sinclair, A and Brown, J E (2016) Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents. Organic & Biomolecular Chemistry, 14, pp. 3069-3079. ISSN (print) 1477-0520

Le Gresley, Adam, Simpson, Emma, Sinclair, Alex, Williams, Neil, Burnett, Gary, Bradshaw, David and Lucas, Robert (2015) The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries. Analytical Methods, 7(6), p. 2323. ISSN (print) 1759-9660

Le Gresley, Adam, Fardus, Fahmina and Warren, John (2015) Bias and uncertainty in non-ideal qNMR Analysis. Critical reviews in analytical chemistry / CRC, 45(4), pp. 300-10. ISSN (print) 1547-6510

Sinclair, Alex, Mulcahy, Lauren, Geldeard, Lynsey, Malik, Samerah, Fielder, Mark and Le Gresley, Adam (2013) Development of an in situ culture-free screening test for the rapid detection of Staphylococcus aureus within healthcare environments. Organic & Biomolecular Chemistry, 11(20), pp. 3307-3313. ISSN (print) 1477-0520

Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam (2012) The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction. Tetrahedron Letters, 53(33), pp. 4280-4282. ISSN (print) 0040-4039

Gresley, Adam le, Kenny, Jackie, Cassar, Claire, Kelly, Alison, Sinclair, Alex and Fielder, Mark D (2012) The application of high resolution diffusion NMR to the analysis of manuka honey. Food Chemistry, 135(4), pp. 2879-86. ISSN (print) 0308-8146

Le Gresley, Adam, Abdullah, Ammara, Chawla, Deepak, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza, Lafon, Shehri and Sinclair, Alex (2011) Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays. MedChemComm, 2(6), pp. 466-470. ISSN (print) 2040-2503

Le Gresley, Adam, Abdullah, Ammara, Desai, Prachi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza and Lafona, Shehri (2010) Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands. Synthetic Communications, 41(16), pp. 2483-2492. ISSN (print) 0039-7911

Le-Gresley, A and Kuhnert, N (2010) The design and synthesis of acrylato and imino derivatives of calix[4]arene for applications in static and dynamic combinatorial libraries. Journal of Chemical Research, 2, pp. 61-67. ISSN (print) 1747-5198

Kuhnert, Nikolai and Le Gresley, Adam (2008) Synthesis of upper rim calix[4]arene carcerands. Tetrahedron Letters, 49(7), pp. 1274-1276. ISSN (print) 0040-4039

Kuhnert, Nikolai, Le Gresley, Adam, Nicolau, Daniel C. and Lopez-Periago, Ana (2007) Synthesis, self-association and chiroselectivity of isotopically labeled trianglamine macrocycles in the ion trap mass spectrometer. Journal of Labelled Compounds and Radiopharmaceuticals, 50(13), pp. 1215-1223. ISSN (print) 0362-4803

Kuhnert, Nikolai and Le Gresley, Adam (2005) Synthesis and capsule formation of upper rim substituted tetra-acrylamido calix[4]arenes. Organic & Biomolecular Chemistry, 3(11), pp. 2175-2182. ISSN (print) 1477-0520

Kuhnert, Nikolai and Le-Gresley, Adam (2005) The use of deep cavity tetraformyl calix[4]arenes in the synthesis of static and dynamic macrocyclic libraries. Tetrahedron Letters, 46(12), pp. 2059-2062. ISSN (print) 0040-4039

Kuhnert, Nikolai and Le-Gresley, Adam (2003) The synthesis of tetra-acrylamido-calix[4]arene capsules. Chemical Communications, 19, pp. 2426-2427. ISSN (print) 1359-7345

Kuhnert, Nikolai and Le Gresley, Adam (2001) On the scope and limitations of the Heck reaction of upper rim tetraiodocalix[4]arenes. Perkin Transactions 1, 24, pp. 3393-3398. ISSN (print) 1472-7781

Book Section

Le Gresley, Adam (2022) Bicyclic 5-5 systems : five heteroatoms 2:3 and six heteroatoms 3:3. In: Al-dabbagh, Fawaz, (ed.) Comprehensive Heterocyclic Chemistry IV. Amsterdam : Elsevier. pp. 120-134. 10 ISBN 9780128186565

Conference or Workshop Item

Durrant, Arija, Peron, Jean-Marie, Le Gresley, Adam and Langat, Moses (2022) Identification and quantification of isolated medicinal compounds by PSYCHE NMR and DOSY NMR. In: Ampere NMR School 2022; 19-25 Jun 2022, Zakopane, Poland. (Unpublished)

Fardus, Fahmina, Warren, John, Le Gresley, Adam and Peron, Jean-Marie (2011) Optimization and uncertainty budgets of externally standardised NMR assays. In: Bruker MR Users' Meeting 2011; 15-16t Nov 2011, Coventry, UK. (Unpublished)

Le Gresley, Adam, Gollapalli, Uma [Contributor] and Ghosh, Uttam [Contributor] (2009) The synthesis of novel G-quadruplex ligands and Host-Guest binding evaluation using DOSY NMR. In: National Cancer Research Institute Cancer Conference; 04 -07 Oct 2009, Birmingham, U.K.. (Unpublished)

Le Gresley, Adam and Kuhnert, Nikolai [Contributor] (2009) The synthesis of novel calix[4]arene tetra-acrylates and their potential use as macrocyclic platforms in the development of static and dynamic combinatorial libraries using reversible imine formation. In: IUPAC Conference; , Glasgow, UK. (Unpublished)

Patent

Sinclair, Alex [Inventor], Fielder, Mark [Inventor] and Le Gresley, Adam [Inventor] (2013) Kingston University Higher Education Corporation Rhodamine based fluorescent probe for coagulase activity and detection of coagulase producing bacterial strains. WO 2014013272 A1.